Codeine - CISMeF

Preferred Label : Codeine;

NCIt definition : A naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions of endogenous opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of mu-subtype opioid receptors results in a decrease in the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the codeine metabolite morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability. Stimulation of gut mu-subtype opioid receptors results in a reduction in intestinal motility and delayed intestinal transit times. Antitussive activity is mediated through codeine's action on the cough center in the medulla.;

UNII : Q830PW7520;

InChIKey : WRRSFOZOETZUPG-FFHNEAJVSA-N;

CAS number : 6059-47-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 6059-47-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C18H21NO3.H2O;

NSC code : 11427;

Codes from synonyms : NSC0011427;

Details

Origin ID

C383;

UMLS CUI

C0009214;

False automatic mappings
- Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified [ICD-10 category (who)]
- Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified [ICD-10 category (who)]
- Other opioids [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of other opioids [ICD-10 Sub-category]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Codeine [LOINC component]
- Codeine (substance) [SNOMED CT concept]
- Codeine, codeine derivatives and other opioids used in cough suppression [ICD-11 Extension code]
- Product containing codeine (medicinal product) [SNOMED CT concept]
- codeine [ATC Code]
- codeine [MeSH concept]
- codeine [SNOMED Notion]
- codeine [MeSH Descriptor]
Validated automatic mappings to BTNT
- codeine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Codeine Phosphate [NCIt concept]
- Codeine Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Codeine Phosphate [NCIt concept]
- Codeine Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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