Preferred Label : Codeine Sulfate;
NCIt synonyms : 7,8-Didehydro-4,5-epoxy- 3-methoxy-17-methyl-(5a,6a)-Morphinan-6-ol Sulfate (2:1);
NCIt related terms : Codeine, sulfate;
NCIt definition : The sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and
opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate
mimics the actions of opioids by binding to the opioid receptors at many sites within
the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates
the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate
cyclase. This results in a decrease in intracellular cAMP and leads to a reduction
in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine
and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite
morphine, which induces opening of G-protein-coupled inwardly rectifying potassium
(GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby
resulting in hyperpolarization and reduced neuronal excitability.;
UNII : 11QV9BS0CB;
InChIKey : BOLDZXRCJAJADM-AAXBYHQXSA-N;
CAS number : 6854-40-6;
Chemical formula : 2C18H21NO3.3H2O.H2SO4;
Codes from synonyms : NSC0011427;
Origin ID : C53137;
UMLS CUI : C0304352;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
