Preferred Label : Codeine Phosphate;
NCIt synonyms : Tricodein; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-alpha)-,
phosphate;
NCIt definition : The phosphate salt of codeine, a naturally occurring phenanthrene alkaloid and opioid
agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the
actions of endogenous opioids by binding to the opioid receptors at many sites within
the central nervous system (CNS). Stimulation of mu-subtype opioid receptors results
in a decrease in the release of nociceptive neurotransmitters such as substance P,
GABA, dopamine, acetylcholine and noradrenaline; in addition, the codeine metabolite
morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK)
channels and blocks the opening of N-type voltage-gated calcium channels, resulting
in hyperpolarization and reduced neuronal excitability. Stimulation of gut mu-subtype
opioid receptors results in a reduction in intestinal motility and delayed intestinal
transit times. Antitussive activity is mediated through codeine's action on the cough
center in the medulla.;
Alternative definition : NCI-GLOSS: A drug used to treat pain, cough, and diarrhea. It is made from opium or
morphine and binds to opioid receptors in the central nervous system. Codeine phosphate
is a type of opiate, a type of analgesic agent, a type of antitussive agent, and a
type of antidiarrheal agent.;
UNII : GSL05Y1MN6;
InChIKey : DKSZLDSPXIWGFO-BLOJGBSASA-N;
CAS number : 41444-62-6;
Chemical formula : 2C18H21NO3.H2O.2H3O4P;
Codes from synonyms : CDR0000546735;
Origin ID : C74548;
UMLS CUI : C0009217;
See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
