NCIt definition : The bitartrate salt form of hydrocodone, a semisynthetic hydrogenated codeine derivative
and opioid agonist with analgesic and antitussive effects. Hydrocodone primarily binds
to and activates the mu-opioid receptor in the central nervous system (CNS). This
leads to analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal
motility, cough suppression and physical dependence. Hydrocodone is converted to hydromorphone
by the cytochrome P450 enzyme CYP2D6.;
Alternative definition : NCI-GLOSS: A drug used to treat moderate to severe pain and cough. Hydrocodone bitartrate
is made from codeine and binds to opioid receptors in the central nervous system.
It is a type of analgesic agent, a type of antitussive, and a type of opiate.;