NCIt definition : A synthetic substance related to natural sympathomimetic amines. Amphetamine appears
to exert its central nervous system (CNS) and peripheral effects indirectly by inducing
the release of biogenic amines from their storage sites in nerve terminals. This agent
is a commonly abused psychostimulant drug, which may be snorted, taken orally, smoked,
or injected. Amphetamine induces psychologic dependence which is manifested by elevated
mood, increased wakefulness, concentration, physical performance and a feeling of
well-being. With sustained use, the effects of tachycardia and enhanced alertness
diminish while psychotoxic effects such as hallucinations and delusions may occur.
(NCI04);