Metoprolol Succinate

Preferred Label : Metoprolol Succinate;

NCIt definition : The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion.;

UNII : TH25PD4CCB;

InChIKey : RGHAZVBIOOEVQX-UHFFFAOYSA-N;

CAS number : 98418-47-4;

Drug name : Toprol XL;

Chemical formula : 2C15H25NO3.C4H6O4;

Codes from synonyms : 32069;

Details

Origin ID

C29254;

UMLS CUI

C0724633;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- metoprolol [MeSH Descriptor]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Metoprolol [NCIt concept]
is_salt_form_of
- Metoprolol [NCIt concept]

Keyword's position in hierarchy(ies) :

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