Flecainide Acetate

Preferred Label : Flecainide Acetate;

NCIt synonyms : Flecainide;

NCIt definition : The acetate salt form of flecainide, a synthetic agent derived from trifluoroethoxy-benzamide exhibiting antiarrhythmic and local anesthetic activity. As a class Ic antiarrhythmic that blocks sodium channels, flecainide depresses polarization phase 0 and decreases the induction velocity of the His-Purkinje system. It also decreases phase 4 slope and increases the depolarization threshold.;

NCIt note : Flecainide is used to prevent paroxysmal supraventricular tachycardias, atrial fibrillations and flutter, and other arrhythmias. It also relieves neuropathic pain from damage to nerves caused by some cancers.;

UNII : M8U465Q1WQ;

InChIKey : RKXNZRPQSOPPRN-UHFFFAOYSA-N;

CAS number : 54143-56-5;

Chemical formula : C17H20F6N2O3.C2H4O2;

NSC code : 719273;

Details

Origin ID

C499;

UMLS CUI

C0086303;

Automatic exact mappings (from CISMeF team)
- Flecainide [ICHI extension code]
- flecainide [EMDN type]
- flecainide [medical devices type]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Flecainide [LOINC component]
- Flecainide [ICD-11 Extension code]
- Flecainide [SMS substance]
- Flecainide (substance) [SNOMED CT concept]
- flecainide [SNOMED Notion]
- flecainide [MeSH concept]
- flecainide [ATC Code]
- flecainide [MeSH Descriptor]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Flecainide [NCIt concept]
is_salt_form_of
- Flecainide [NCIt concept]

Keyword's position in hierarchy(ies) :

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