Perphenazine - CISMeF

Preferred Label : Perphenazine;

NCIt related terms : 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol;

NCIt definition : A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.;

UNII : FTA7XXY4EZ;

InChIKey : RGCVKNLCSQQDEP-UHFFFAOYSA-N;

CAS number : 58-39-9;

Chemical formula : C21H26ClN3OS;

NSC code : 150866;

ChEBI ID : CHEBI:8028;

Codes from synonyms : 06627;

Details

Origin ID

C29355;

UMLS CUI

C0031184;

Automatic exact mappings (from CISMeF team)
- Perphenazine [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Perphenazine [ICD-11 Extension code]
- Perphenazine [LOINC component]
- Perphenazine (substance) [SNOMED CT concept]
- Product containing perphenazine (medicinal product) [SNOMED CT concept]
- perphenazine [ATC Code]
- perphenazine [Substance BNPC]
- perphenazine [MeSH concept]
- perphenazine [MeSH Descriptor]
- perphenazine [SNOMED Notion]
Validated automatic mappings to BTNT
- perphenazine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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