Bisoprolol Fumarate

Preferred Label : Bisoprolol Fumarate;

NCIt synonyms : Bisoprolol Hemifumarate; ( -)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt);

NCIt definition : The fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting activation of the renin-angiotensin system (RAS). Bisoprolol has been shown to be cardioprotective in animal models.;

UNII : UR59KN573L;

InChIKey : VMDFASMUILANOL-WXXKFALUSA-N;

CAS number : 104344-23-2;

Chemical formula : 2C18H31NO4.C4H4O4;

ChEBI ID : CHEBI:3128;

Codes from synonyms : 01563;

Details

Origin ID

C28871;

UMLS CUI

C0543473;

See also inter- (CISMeF)
- Bisoprolol fumarate (product) [Inactive SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Bisoprolol (substance) [SNOMED CT concept]
- bisoprolol [MeSH Descriptor]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Bisoprolol [NCIt concept]
is_salt_form_of
- Bisoprolol [NCIt concept]

Keyword's position in hierarchy(ies) :

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