NCIt definition : A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and
devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively
binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac
contractility and rate. This leads to a reduction in cardiac output and lowers blood
pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted
by the kidneys that causes constriction of blood vessels.;