Loratadine - CISMeF

Preferred Label : Loratadine;

NCIt synonyms : 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, Ethyl Ester;

NCIt definition : A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.;

UNII : 7AJO3BO7QN;

InChIKey : JCCNYMKQOSZNPW-UHFFFAOYSA-N;

CAS number : 79794-75-5;

Drug name : Claritin;

Chemical formula : C22H23ClN2O2;

NSC code : 721075;

Details

Origin ID

C29162;

UMLS CUI

C0065180;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Loratadine [ICD-11 Extension code]
- Loratadine [LOINC component]
- Loratadine (substance) [SNOMED CT concept]
- Product containing loratadine (medicinal product) [SNOMED CT concept]
- loratadine [ATC Code]
- loratadine [Substance BNPC]
- loratadine [MeSH concept]
- loratadine [MeSH Descriptor]
Validated automatic mappings to BTNT
- loratadine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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