Clozapine - CISMeF

Preferred Label : Clozapine;

NCIt synonyms : 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine;

NCIt definition : A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04);

UNII : J60AR2IKIC;

InChIKey : QZUDBNBUXVUHMW-UHFFFAOYSA-N;

CAS number : 5786-21-0;

Chemical formula : C18H19ClN4;

ChEBI ID : CHEBI:3766;

Details

Origin ID

C28936;

UMLS CUI

C0009079;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clozapine [ICD-11 Extension code]
- Clozapine (substance) [SNOMED CT concept]
- Product containing clozapine (medicinal product) [SNOMED CT concept]
- cloZAPine [LOINC component]
- clozapine [ATC Code]
- clozapine [Substance BNPC]
- clozapine [International Nonproprietary Name]
- clozapine [MeSH concept]
- clozapine [MeSH Descriptor]
- clozapine [SNOMED Notion]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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