clozapine - CISMeF

Preferred Label : clozapine;

MeSH definition : A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.;

MeSH hyponym : leponex; clozaril;

MeSH CAS label : 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-;

MeSH Related Number : 5786-21-0 (Clozapine);

Registry Number MeSH : 5786-21-0;

Wikipedia link : https://en.wikipedia.org/wiki/Clozapine;

Codes EINECS : 227-313-7;

Is substance : O;

UNII : J60AR2IKIC;

InChIKey : QZUDBNBUXVUHMW-UHFFFAOYSA-N;

Details

Origin ID

D003024;

UMLS CUI

C0009079;

ATC code(s)
- clozapine [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Clozapine (substance) [SNOMED CT concept]
- Clozapine adverse reaction (disorder) [SNOMED CT concept]
- Clozapine measurement (procedure) [SNOMED CT concept]
- Clozapine poisoning (disorder) [SNOMED CT concept]
- clozapine [Substance BNPC]
Exact mapping(s) to DCI
- clozapine [International Nonproprietary Name]
Pharmacological action(s)
- GABA antagonists [MeSH Descriptor]
- antipsychotic agents [MeSH Descriptor]
- central nervous system depressants [MeSH Descriptor]
- psychotropic drugs [MeSH Descriptor]
- serotonin antagonists [MeSH Descriptor]
Record concept(s)
- clozapine [MeSH concept]
- clozaril [MeSH concept]
- leponex [MeSH concept]
Related MeSH Supplementary Concept(s)
- 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine [MeSH Supplementary Concept]
- 2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine [MeSH Supplementary Concept]
- CGS 19649A [MeSH Supplementary Concept]
- CGS 22996 [MeSH Supplementary Concept]
- JL 13 compound [MeSH Supplementary Concept]
- JL 18 [MeSH Supplementary Concept]
- N-piperonylclozapine [MeSH Supplementary Concept]
- batelapine [MeSH Supplementary Concept]
- clozapine N-glucuronide [MeSH Supplementary Concept]
- clozapine N-oxide [MeSH Supplementary Concept]
- demethylclozapine [MeSH Supplementary Concept]
- deschloroclozapine [MeSH Supplementary Concept]
- dibenzo(c,e)azepine [MeSH Supplementary Concept]
- iozapine [MeSH Supplementary Concept]
- norclozapine [MeSH Supplementary Concept]
- seleptin [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing clozapine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clozapine [ICD-11 Extension code]
- Clozapine [NCIt concept]
- Clozapine (substance) [SNOMED CT concept]
- Product containing clozapine (medicinal product) [SNOMED CT concept]
- cloZAPine [LOINC component]
- clozapine [ATC Code]
- clozapine [Substance BNPC]
- clozapine [International Nonproprietary Name]
- clozapine [SNOMED Notion]
Validated automatic mappings to BTNT
- clozapine [ATC Code]

Keyword's position in hierarchy(ies) :

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