Preferred Label : Caffeine;
NCIt synonyms : 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; 1,3,7-trimethylxanthine; CAF;
NCIt related terms : Theine; Methyltheobromine; Trimethylxanthine;
NCIt definition : A methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants
native to South America and East Asia that is structurally related to adenosine and
acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory
activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous
system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated
downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal,
vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter
release that further stimulates the CNS. The anti-inflammatory effects of caffeine
are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition
of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein
kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation
and innate immunity.;
Alternative definition : CRCH: An alkaloid stimulant having a purine double-ring structure composed of eight
carbons and four nitrogen atoms with methyl groups attached to the nitrogen atoms
at the 1, 3, and 7 positions and having double bonds at the carbons in positions 2
and 6.; NCI-GLOSS: A substance found in the leaves and beans of the coffee tree, in tea, yerba
mate, guarana berries, and in small amounts in cocoa. It can also be made in the laboratory,
and is added to some soft drinks, foods, and medicines. Caffeine increases brain activity,
alertness, attention, and energy. It may also increase blood pressure, heart rate,
breathing rate, and the loss of water from the body in urine.;
UNII : 3G6A5W338E;
InChIKey : RYYVLZVUVIJVGH-UHFFFAOYSA-N;
CAS number : 58-08-2;
Unit used : mg;
Chemical formula : C8H10N4O2;
NSC code : 5036;
ChEBI ID : CHEBI:27732;
Codes from synonyms : CDR0000454809; NSC0005036; 00344;
Origin ID : C328;
UMLS CUI : C0006644;
Semantic type(s)
UMLS correspondences (same concept)
chemical_or_drug_is_metabolized_by_enzyme
concept_is_in_subset
has_salt_form
is_component_of_chemotherapy_regimen
is_free_acid_or_base_form_of
https://www.cochrane.org/fr/CD015802/NEONATAL_quel-est-le-meilleur-moment-pour-arreter-de-donner-de-la-cafeine-aux-nouveau-nes-prematures
2024
United Kingdom
review of literature
french abstract
Stop
Preterm Infant
premature birth of newborn, nos
caffeine
Caffeine Measurement
infant, newborn
Caffeine
caffeine, nos
Give
premature newborn
What Month is it
Best
infant, premature
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