NCIt definition : A synthetic long-acting polymer derivative of the female sex hormone estradiol. As
the primary, most potent estrogen hormone produced by the ovaries, estradiol binds
to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and
metabolic properties, and increases blood coagulability. Administration of polyestradiol
phosphate leads to the marked decrease of testosterone levels and may exhibit a bone
mass-preserving effect in patients with prostatic cancer. (NCI04);