Acetaminophen - CISMeF

Preferred Label : Acetaminophen;

NCIt synonyms : N-(4-Hydroxyphenyl)acetamide; 4-Hydroxyacetanilide; APAP;

NCIt related terms : Paracetamol; Tylenol;

NCIt definition : A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus.;

Alternative definition : NCI-GLOSS: A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics.;

UNII : 362O9ITL9D;

InChIKey : RZVAJINKPMORJF-UHFFFAOYSA-N;

CAS number : 103-90-2;

Drug name : Tylenol;

Chemical formula : C8H9NO2;

NSC code : 109028; 3991;

ChEBI ID : CHEBI:46195;

Codes from synonyms : NSC0003991; 00589; CDR0000045165; 8;

Details

Origin ID

C198;

UMLS CUI

C0000970;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Acetaminophen [LOINC component]
- Paracetamol (substance) [SNOMED CT concept]
- Product containing paracetamol (medicinal product) [SNOMED CT concept]
- acetaminophen [SNOMED Notion]
- acetaminophen [MeSH Descriptor]
- acetaminophen [MeSH concept]
- paracetamol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2E1 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Acetaminophen/Acetylcysteine [NCIt concept]
- Acetaminophen/Acetylcysteine/Carmustine [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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