" /> Warfarin - CISMeF





Preferred Label : Warfarin;

NCIt synonyms : 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin; 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin; 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one;

NCIt related terms : 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin; 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin; WARF compound 42; Compound 42;

NCIt definition : A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.;

Alternative definition : NCI-GLOSS: A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).; ACC/AHA: A vitamin K antagonist anticoagulant;

UNII : 5Q7ZVV76EI;

InChIKey : PJVWKTKQMONHTI-UHFFFAOYSA-N;

CAS number : 81-81-2;

Drug name : WARF Compound 42; Co-Rax; Rodex; Compound 42;

Chemical formula : C19H16O4;

NSC code : 59813;

ChEBI ID : CHEBI:10033;

Codes from synonyms : NSC0059813; CDR0000045249; 547;

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29/05/2025


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