" /> Flutamide - CISMeF





Preferred Label : Flutamide;

NCIt synonyms : 4'-Nitro-3'-trifluoromethylisobutyranilide; Flucinom; Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide; Niftolide; Flugerel; FLUT; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Eulexin; Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-;

NCIt related terms : Sch 13521;

NCIt definition : A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that is a type of antiandrogen.;

UNII : 76W6J0943E;

InChIKey : MKXKFYHWDHIYRV-UHFFFAOYSA-N;

CAS number : 13311-84-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 13311-84-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Eulexine; Fugerel; Profamid; Fluta-Gry; Prostica; Fluken; Prostacur; Drogenil; Oncosal; Flutamin; Prostadirex; Flutan; Flutacan; Flutamex; Grisetin; Flutaplex; Euflex; Testotard; Chimax; Apimid; Prostogenat; Flucinome; Flulem; Flutabene; Tecnoflut; Tafenil; Cytomid; Cebatrol;

Molecule name : SCH 13521;

Chemical formula : C11H11F3N2O3;

NSC code : 147834; 215876;

ChEBI ID : CHEBI:5132;

Codes from synonyms : CDR0000045264; NSC0215876; 01895; 227;

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12/05/2024


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