Androgen Receptor

Preferred Label : Androgen Receptor;

NCIt synonyms : Nuclear Receptor Subfamily 3 Group C Member 4; Dihydrotestosterone Receptor; AR; NR3C4; DHTR;

NCIt definition : Androgen receptor (919 aa, 99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription.;

NCIt note : AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription.;

Details

Origin ID

C17063;

UMLS CUI

C1447749;

Currated CISMeF NLP mapping
- Androgen receptor (substance) [SNOMED CT concept]
- androgen receptor site [SNOMED Notion]
- receptors, androgen [MeSH Descriptor]
- receptors, androgen [MeSH concept]
OMIM relation
- Androgen receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- AR protein, human [MeSH Supplementary Concept]
- AR protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- AR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- AR Antagonist BMS-641988 [NCIt concept]
- Androgen Receptor Antagonist TRC253 [NCIt concept]
- Androgen Receptor Degrader CC-94676 [NCIt concept]
- Androgen Receptor Downregulator AZD3514 [NCIt concept]
- Androgen Receptor Inhibitor ONCT-534 [NCIt concept]
- Bavdegalutamide [NCIt concept]
- Darolutamide [NCIt concept]
- Flutamide [NCIt concept]
- Masofaniten [NCIt concept]
- Ralaniten Acetate [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Gene Expression [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- 2-Hydroxyflutamide Depot [NCIt concept]
- AR Antagonist BMS-641988 [NCIt concept]
- Androgen Antagonist APC-100 [NCIt concept]
- Androgen Receptor Antagonist BAY 1161116 [NCIt concept]
- Androgen Receptor Antagonist ONC1-0013B [NCIt concept]
- Androgen Receptor Antagonist TAS3681 [NCIt concept]
- Androgen Receptor Antagonist TQB3720 [NCIt concept]
- Androgen Receptor Antagonist TRC253 [NCIt concept]
- Androgen Receptor Antisense Oligonucleotide AZD5312 [NCIt concept]
- Androgen Receptor Degrader AC176 [NCIt concept]
- Androgen Receptor Degrader CC-94676 [NCIt concept]
- Androgen Receptor Degrader RO7656594 [NCIt concept]
- Androgen Receptor Downregulator AZD3514 [NCIt concept]
- Androgen Receptor Inhibitor ONCT-534 [NCIt concept]
- Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10 [NCIt concept]
- Androstane Steroid HE3235 [NCIt concept]
- Apalutamide [NCIt concept]
- Bavdegalutamide [NCIt concept]
- Bicalutamide [NCIt concept]
- CYP17/Androgen Receptor Inhibitor ODM 204 [NCIt concept]
- Clascoterone [NCIt concept]
- Cyproterone [NCIt concept]
- Cyproterone Acetate [NCIt concept]
- Darolutamide [NCIt concept]
- Deutenzalutamide [NCIt concept]
- Enobosarm [NCIt concept]
- Enzalutamide [NCIt concept]
- Flutamide [NCIt concept]
- Galeterone [NCIt concept]
- Hydroxyflutamide [NCIt concept]
- Iodine I 123 RISAD-P [NCIt concept]
- Iodine I 125 RISAD-P [NCIt concept]
- Luxdegalutamide [NCIt concept]
- Masofaniten [NCIt concept]
- Nilutamide [NCIt concept]
- Proxalutamide [NCIt concept]
- Ralaniten Acetate [NCIt concept]
- Rezvilutamide [NCIt concept]
- Selective Androgen Receptor Modulator LY2452473 [NCIt concept]
- Testosterone Cypionate [NCIt concept]
- Testosterone Enanthate [NCIt concept]
- Testosterone Gel [NCIt concept]
- Testosterone Nasal Gel [NCIt concept]
- Testosterone Vaginal Cream [NCIt concept]
- Therapeutic Testosterone [NCIt concept]
- Vosilasarm [NCIt concept]

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