Preferred Label : Androgen Receptor Antagonist TAS3681;
NCIt synonyms : Androgen Receptor Inhibitor TAS3681; AR Antagonist TAS3681;
NCIt definition : An orally bioavailable inhibitor of the androgen receptor (AR), with potential antineoplastic
activity. Upon oral administration, AR inhibitor TAS3681 specifically binds to AR.
This prevents AR activation, downregulates AR and prevents AR-mediated signaling.
This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in
prostate cancers and is involved in proliferation, survival and chemoresistance of
tumor cells.;
Molecule name : TAS3681; TAS 3681;
NCI Metathesaurus CUI : CL524893;
Origin ID : C137818;
UMLS CUI : C4528703;
Semantic type(s)
- concept_is_in_subset
- has_target
