Androstane Steroid HE3235

Preferred Label : Androstane Steroid HE3235;

NCIt synonyms : 17Alpha-ethynyl-5alpha-androstane-3alpha, 17Beta-diol; Adrenal Steroid Analogue HE3235;

NCIt related terms : APOPTONE;

NCIt definition : An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.;

UNII : 891O182ZP5;

CAS number : 183387-50-0;

Drug name : APOPTONE;

Molecule name : HE3235;

Détails

Origin ID

C78831;

UMLS CUI

C2715313;

Automatic exact mappings (from CISMeF team)
- 17-ethynylandrostane-3,17-diol [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- 17alpha-ethynyl-5alpha-androstane-3alpha,17beta-diol [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HE 3235 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Androgen Receptor [NCIt concept]

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