" /> Androstane Steroid HE3235 - CISMeF





Preferred Label : Androstane Steroid HE3235;

NCIt synonyms : 17Alpha-ethynyl-5alpha-androstane-3alpha, 17Beta-diol; Adrenal Steroid Analogue HE3235;

NCIt related terms : APOPTONE;

NCIt definition : An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.;

UNII : 891O182ZP5;

CAS number : 183387-50-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 183387-50-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : APOPTONE;

Molecule name : HE3235;

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09/05/2024


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