Selective Androgen Receptor Modulator LY2452473

Preferred Label : Selective Androgen Receptor Modulator LY2452473;

NCIt synonyms : SARM LY2452473; Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate; LY SARM;

NCIt related terms : OPK-88004;

NCIt definition : An orally bioavailable selective androgen receptor modulator (SARM), with potential tissue-selective androgenic/anti-androgenic activity. Upon oral administration, LY2452473 acts as an agonist in select tissues and organs, including skeletal muscle, bone and the penis, thereby binding to and activating androgen receptor (AR) while acting as an antagonist in the prostate, thereby blocking AR activation and AR-mediated cellular proliferation. This may improve muscle mass and strength, bone formation, and erectile dysfunction while not stimulating growth of the prostate.;

UNII : XKW9MYF94Y;

CAS number : 1029692-15-6;

Molecule name : LY2452473;

Details

Origin ID

C123792;

UMLS CUI

C3658612;

Currated CISMeF NLP mapping
- LY2452473 [MeSH Supplementary Concept]
- LY2452473 [MeSH concept]
False automatic mappings
- Humerus [LOINC System]
- humerus [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LY2452473 [MeSH Supplementary Concept]
- LY2452473 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Androgen Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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