Preferred Label : Androgen Receptor Antagonist ONC1-0013B;
NCIt synonyms : AR Antagonist ONC1-0013B; (R)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diazaspiro[4.4]nonan-1-yl)-2-fluoro-N-methylbenzamide;
NCIt related terms : ONC1-13B;
NCIt definition : An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic
activity. Upon oral administration, AR antagonist ONC1-13B specifically binds to AR,
prevents AR activation, downregulates AR expression and prevents AR-mediated signaling.
This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in
prostate cancers and is involved in proliferation, survival and chemoresistance of
tumor cells.;
UNII : JFG7JWH6YL;
Molecule name : ONC-10013B; ONC1-13B; ONC 10013B; ONC 113B;
NCI Metathesaurus CUI : CL551056;
Origin ID : C148485;
UMLS CUI : C4725068;
Semantic type(s)
- concept_is_in_subset
- has_target
