" /> Androgen Receptor Antagonist TRC253 - CISMeF





Preferred Label : Androgen Receptor Antagonist TRC253;

NCIt synonyms : AR Antagonist TRC253;

NCIt related terms : TRC-253;

NCIt definition : An orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.;

UNII : GNG9GQ9Y27;

Molecule name : TRC 253; TRC-253; JNJ 63576253; JNJ-63576253;

NCI Metathesaurus CUI : CL520350;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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