Preferred Label : Galeterone;
NCIt synonyms : Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001; Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-;
NCIt definition : An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase
inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct
mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor
and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all
of which may result in a decrease in androgen-dependent growth signaling. Localized
to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1)
exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role
in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids,
androgens, and estrogens.;
UNII : WA33E149SW;
InChIKey : PAFKTGFSEFKSQG-PAASFTFBSA-N;
CAS number : 851983-85-2;
Molecule name : TOK-001; VN/124-1; VN/124; TOK 001;
Chemical formula : C26H32N2O;
Codes from synonyms : 239;
Origin ID : C84866;
UMLS CUI : C1569219;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
