Steroid 17-Alpha-Hydroxylase/17,20 Lyase

Preferred Label : Steroid 17-Alpha-Hydroxylase/17,20 Lyase;

NCIt synonyms : CYPXVII; CYP17A1; Cytochrome-P450-XVIIA1; Cytochrome P450 Subfamily XVII (Steroid 17-Alpha-Hydroxylase); Steroid 17-Alpha-Hydroxylase; Steroid 17-Alpha-Monooxygenase; P450-C17; Cytochrome P450 Family 17; Cytochrome P450c17; EC 1.14.99.9; Cytochrome P450 17A1; Cytochrome P450 XVIIA1; Cytochrome P450-C17;

NCIt definition : Steroid 17-alpha-hydroxylase/17,20 lyase (508 aa, 57 kDa) is encoded by the human CYP17A1 gene. This protein is involved in steroid metabolism and sexual maturation.;

NCIt note : Steroid 17-alpha-hydroxylase/17,20 lyase converts pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. (UniProt);

Details

Origin ID

C40068;

UMLS CUI

C1570773;

Currated CISMeF NLP mapping
- Steroid 17-alpha-monooxygenase (substance) [SNOMED CT concept]
- steroid 17-alpha-monooxygenase [SNOMED Notion]
OMIM relation
- Cytochrome p450, family 17, subfamily a, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 17 alpha-Hydroxylase [LOINC component]
- CYP17A1 protein, human [MeSH Supplementary Concept]
- CYP17A1 protein, human [MeSH concept]
- Steroid 17-alpha-monooxygenase (substance) [SNOMED CT concept]
- steroid 17-alpha-Hydroxylase [MeSH concept]
- steroid 17-alpha-hydroxylase [MeSH Descriptor]
- steroid 17-alpha-monooxygenase [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CYP17A1 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Abiraterone Acetate [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Sexual Maturation [NCIt concept]
is_target
- Abiraterone [NCIt concept]
- Abiraterone Acetate [NCIt concept]
- Abiraterone Acetate/Niraparib [NCIt concept]
- Abiraterone Amorphous Solid Dispersion Formulation DST-2970 [NCIt concept]
- Abiraterone Decanoate [NCIt concept]
- Abiraterone Decanoate Depot [NCIt concept]
- CYP17 Lyase Inhibitor ASN001 [NCIt concept]
- CYP17/Androgen Receptor Inhibitor ODM 204 [NCIt concept]
- CYP17/CYP11B2 Inhibitor LAE001 [NCIt concept]
- Galeterone [NCIt concept]
- Orteronel [NCIt concept]
- Seviteronel [NCIt concept]

Keyword's position in hierarchy(ies) :

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