Preferred Label : Seviteronel;
NCIt synonyms : 1H-1,2,3-Triazole-5-methanol, Alpha-(6,7-bis(difluoromethoxy)-2-naphthalenyl)-alpha-(1-methylethyl)-,
(AlphaS)-;
NCIt definition : An orally available non-steroidal, lyase-selective inhibitor of the steroid 17-alpha-hydroxylase/C17,20
lyase (CYP17A1 or CYP17), with potential anti-androgenic and antineoplastic activities.
Upon oral administration, seviteronel selectively inhibits the enzymatic activity
of the cytochrome P450 C17,20 lyase in both the testes and adrenal glands, thereby
inhibiting androgen production. This may decrease androgen-dependent growth signaling
and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome
P450 enzyme CYP17A1, localized to the endoplasmic reticulum, exhibits both 17alpha-hydroxylase
and 17,20-lyase activities; it plays a key role in the steroidogenic pathway. The
lyase-selective activity of seviteronel prevents the increased synthesis of mineralocorticoids
that is normally seen with non-selective CYP17 inhibitors, which also inhibit the
17-alpha-hydroxylase activity of CYP17A1.;
UNII : 8S5OIN36X4;
InChIKey : ZBRAJOQFSNYJMF-SFHVURJKSA-N;
CAS number : 1610537-15-9;
Molecule name : VT-464;
Origin ID : C113652;
UMLS CUI : C4331277;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
