Preferred Label : Abiraterone Amorphous Solid Dispersion Formulation DST-2970;
NCIt synonyms : Abiraterone KinetiSol Formulation DST-2970;
NCIt definition : An orally bioavailable, amorphous solid dispersion formulation of the steroidal compound
abiraterone, with potential antiandrogen activity. Upon oral administration, abiraterone
inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20
lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the
17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis.
This may suppress testosterone production by both the testes and the adrenals to castrate-range
levels.;
Molecule name : DST-2970; DST 2970;
NCI Metathesaurus CUI : CL1413145;
Origin ID : C175940;
UMLS CUI : C5446868;
Semantic type(s)
- concept_is_in_subset
- has_target
