steroid 17-alpha-hydroxylase

Preferred Label : steroid 17-alpha-hydroxylase;

MeSH definition : A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.;

MeSH synonym : cyp17; cytochrome p450(17 alpha); cytochrome p-450(17-alpha); steroid-17-hydroxylase; 17 alpha hydroxylase; 17 alpha hydroxylase cytochrome p 450; 17 alpha-monooxygenase, steroid; 17-hydroxylase, steroid; 17-monooxygenase, steroid; 17,20 desmolase; p450(c17); 17 alpha-hydroxylase cytochrome p-450; cytochrome p-450(17 alpha); 17-alpha-hydroxylase, steroid; 17 alpha-hydroxylase, steroid; steroid 17-hydroxylase; steroid 17 hydroxylase; steroid 17-monooxygenase; steroid 17 monooxygenase; 17,20-desmolase; 17,20-lyase; 17,20 lyase; steroid 17 alpha-monooxygenase; steroid 17 alpha monooxygenase; alpha-monooxygenase, steroid 17; 17 alpha-hydroxylase; steroid 17 alpha hydroxylase; steroid 17 alpha-Hydroxylase;

CISMeF synonym : alpha-hydroxylase, 17;

MeSH hyponym : 17 alpha-Hydroxyprogesterone aldolase; 17 alpha Hydroxyprogesterone Aldolase; Aldolase, 17 alpha-Hydroxyprogesterone; alpha-Hydroxyprogesterone Aldolase, 17; Hydroxyprogesterone Aldolase; Aldolase, Hydroxyprogesterone;

MeSH CAS label : steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating);

MeSH Related Number : 62213-24-5 (CAS RN); 9029-67-8 (CAS RN);

Registry Number MeSH : EC 1.14.99.9; EC 1.14.14.19;

Wikipedia link : https://en.wikipedia.org/wiki/Cyp17;

Is substance : O;

UNII : EC 1.14.14.19;

Details

Origin ID

D013254;

UMLS CUI

C0038302;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 17alpha-hydroxyprogesterone aldolase [SNOMED Notion]
- 17alpha-hydroxyprogesterone aldolase (substance) [SNOMED CT concept]
- CYP17A1 wt Allele [NCIt concept]
- Cytochrome p450, family 17, subfamily a, polypeptide 1 [OMIM gene]
- cytochrome P450 family 17 subfamily A member 1 [ORDO Gene]
- steroid 17-alpha-monooxygenase activity [GO term]
Currated CISMeF NLP mapping
- 17 alpha-Hydroxylase [LOINC component]
- Steroid 17-Alpha-Hydroxylase/17,20 Lyase [NCIt concept]
- Steroid 17-alpha-monooxygenase (substance) [SNOMED CT concept]
- steroid 17-alpha-monooxygenase [SNOMED Notion]
Indexing information
- 1-methyl-2-(1-hydroxyiminoethyl)-6-methoxy-3,4-dihydronaphthalene [MeSH Supplementary Concept]
- 16 beta-bromo-3 beta,17 alpha-dihydroxy-5 alpha-pregnane-11,20-dione [MeSH Supplementary Concept]
- 17 beta-ureido-1,4-androstadien-3-one [MeSH Supplementary Concept]
- 17-(3-pyridyl)-16,17-epoxy-5alpha-androst-3-ol [MeSH Supplementary Concept]
- 17-(4-pyridyl)androst-5-en-3-ol [MeSH Supplementary Concept]
- 17-(cyclopropylamino)androst-5-en-3-ol [MeSH Supplementary Concept]
- 20-hydroxy-21,21,21,-trifluoropregn-4-en-3-one [MeSH Supplementary Concept]
- 22-amino-23,24-bisnor-5-cholen-3-ol [MeSH Supplementary Concept]
- 22-iminopregn-5-en-3-ol [MeSH Supplementary Concept]
- 3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene [MeSH Supplementary Concept]
- 3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene [MeSH Supplementary Concept]
- 4'-(pyridin-4-ylmethyl)biphenyl-3,4-diol [MeSH Supplementary Concept]
- 4'-(pyridin-4-ylmethyl)biphenyl-3-amine [MeSH Supplementary Concept]
- 4-tert-butylcyclohexyl 4-pyridylacetate [MeSH Supplementary Concept]
- YM 116 [MeSH Supplementary Concept]
Record concept(s)
- 17 alpha-Hydroxyprogesterone aldolase [MeSH concept]
- steroid 17-alpha-Hydroxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP17A1 protein, human [MeSH Supplementary Concept]
- CYP17A1 protein, rat [MeSH Supplementary Concept]
- Cyp17a1 protein, mouse [MeSH Supplementary Concept]
- cyp17a1 protein, zebrafish [MeSH Supplementary Concept]
- cyp17a2 protein, zebrafish [MeSH Supplementary Concept]
- pregnenolone 17-alpha-hydroxylase [MeSH Supplementary Concept]
- progesterone 17-alpha-hydroxylase [MeSH Supplementary Concept]
Related MeSH term(s)
- adrenal hyperplasia, congenital [MeSH Descriptor]
See also
- adrenal hyperplasia, congenital [MeSH Descriptor]
See also (suggested by CISMeF)
- adrenal hyperplasia, congenital, type 5 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 17 alpha-Hydroxylase [LOINC component]
- Steroid 17-Alpha-Hydroxylase/17,20 Lyase [NCIt concept]
- Steroid 17-alpha-monooxygenase (substance) [SNOMED CT concept]
- steroid 17-alpha-monooxygenase [SNOMED Notion]

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