Preferred Label : Abiraterone Decanoate Depot;
NCIt synonyms : PRL-02 Depot;
NCIt definition : A depot formulation containing the decanoate ester of abiraterone, a steroidal compound
with antiandrogen activity. Upon administration, abiraterone inhibits the enzymatic
activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex;
CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation
of steroid intermediates involved in testosterone synthesis. This suppresses testosterone
production by both the testes and the adrenals to castrate-range levels. This may
decrease androgen-dependent growth signaling and inhibit the proliferation of androgen-dependent
tumor cells.;
Molecule name : PRL-02; PRL 02;
NCI Metathesaurus CUI : CL1662159;
Origin ID : C179617;
UMLS CUI : C5555818;
Semantic type(s)
- concept_is_in_subset
- has_target
