NCIt definition : The decanoate form of abiraterone, a steroidal compound with antiandrogen activity.
Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20
lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the
17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis.
Administration of this agent may suppress testosterone production by both the testes
and the adrenals to castrate-range levels.;
Semantic type(s)