Preferred Label : Orteronel;
NCIt synonyms : Androgen Synthesis Inhibitor TAK-700; CYP17A1 Lyase Inhibitor TAK-700; 6-((7S)-7-hydroxy-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide;
NCIt definition : An orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase
(17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits
the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting
androgen production. This may decrease androgen-dependent growth signaling and may
inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450
enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both
17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic
pathway that produces steroidal hormones, such as progestins, mineralocorticoids,
glucocorticoids, androgens, and estrogens.;
UNII : UE5K2FNS92;
InChIKey : OZPFIJIOIVJZMN-SFHVURJKSA-N;
CAS number : 566939-85-3;
Molecule name : TAK-700; TAK 700;
Codes from synonyms : 374;
Origin ID : C90582;
UMLS CUI : C2983781;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
