" /> Abiraterone Acetate - CISMeF





Preferred Label : Abiraterone Acetate;

NCIt synonyms : Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3beta)-; 17-(3-Pyridyl)-5,16-androstadien-3beta-acetate;

NCIt definition : An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of prostate cancer and breast cancer. It blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of cancer cells that need androgens to grow. It is a type of anti-androgen.;

UNII : EM5OCB9YJ6;

InChIKey : UVIQSJCZCSLXRZ-UBUQANBQSA-N;

CAS number : 154229-18-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 154229-18-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zytiga; Yonsa;

Molecule name : CB7630; BR9004; BR9004-1; JNJ-212082;

Chemical formula : C26H33NO2;

Codes from synonyms : CDR0000641969;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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