NCIt definition : An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen
activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase
(17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that
catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone
synthesis. Administration of this agent may suppress testosterone production by both
the testes and the adrenals to castrate-range levels.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of prostate cancer and breast
cancer. It blocks tissues from making androgens (male hormones), such as testosterone.
This may cause the death of cancer cells that need androgens to grow. It is a type
of anti-androgen.;
UNII : EM5OCB9YJ6;
InChIKey : UVIQSJCZCSLXRZ-UBUQANBQSA-N;
CAS number : 154229-18-2;
Drug name : Zytiga; Yonsa;
Molecule name : CB-7630; BR9004; BR9004-1; JNJ-212082; CB 7630;