Steroid Hormone Biosynthesis Pathway

Preferred Label : Steroid Hormone Biosynthesis Pathway;

NCIt synonyms : C21-Steroid Hormone Metabolism Pathway;

NCIt related terms : Steroid Hormone Biosynthesis; C21-Steroid Hormone Metabolism; Androgen and Estrogen Metabolism;

Alternative definition : KEGG: Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland.;

NCIt note : KEGG merged hsa00150 with hsa00140.;

KEGG ID : hsa00140;

Details

Origin ID

C38800;

UMLS CUI

C2981164;

Automatic exact mappings (from CISMeF team)
- C21-steroid hormone metabolic process [GO term]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 11-Beta-Hydroxysteroid Dehydrogenase 1 [NCIt concept]
- 11-Beta-Hydroxysteroid Dehydrogenase Type 2 [NCIt concept]
- 17-Beta-Hydroxysteroid Dehydrogenase Type 6 [NCIt concept]
- 25-Hydroxycholesterol 7-Alpha-Hydroxylase [NCIt concept]
- 25-Hydroxyvitamin D-1 Alpha-Hydroxylase, Mitochondrial [NCIt concept]
- 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type 1 [NCIt concept]
- 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type 2 [NCIt concept]
- 3-Beta-Hydroxysteroid-Delta(8),Delta(7)-Isomerase [NCIt concept]
- 3-Keto-Steroid Reductase [NCIt concept]
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 1 [NCIt concept]
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 [NCIt concept]
- Aldo-Keto Reductase Family 1 Member C1 [NCIt concept]
- Aldo-Keto Reductase Family 1 Member C2 [NCIt concept]
- Aldo-Keto Reductase Family 1 Member C3 [NCIt concept]
- Aromatase [NCIt concept]
- Catechol O-Methyltransferase [NCIt concept]
- Cholesterol 7-Alpha-Monooxygenase [NCIt concept]
- Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial [NCIt concept]
- Cytochrome P450 11B2, Mitochondrial [NCIt concept]
- Cytochrome P450 1A1 [NCIt concept]
- Cytochrome P450 1B1 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
- Cytochrome P450 CYP11B1, Mitochondrial [NCIt concept]
- Estradiol 17-Beta-Dehydrogenase 1 [NCIt concept]
- Estradiol 17-Beta-Dehydrogenase 2 [NCIt concept]
- Estrogen Sulfotransferase [NCIt concept]
- Steroid 17-Alpha-Hydroxylase/17,20 Lyase [NCIt concept]
- Steroid 21-Hydroxylase [NCIt concept]
- UDP-Glucuronosyltransferase 1-1 [NCIt concept]
- UDP-Glucuronosyltransferase 1-4 [NCIt concept]
- UDP-Glucuronosyltransferase 1-7 [NCIt concept]
- UDP-Glucuronosyltransferase 1-9 [NCIt concept]
- UDP-Glucuronosyltransferase 2B15 [NCIt concept]
- UDP-Glucuronosyltransferase 2B17 [NCIt concept]
- Very-Long-Chain 3-Oxoacyl-CoA Reductase [NCIt concept]
- Vitamin D 25-Hydroxylase [NCIt concept]
pathway_has_gene_element
- AKR1C1 wt Allele [NCIt concept]
- AKR1C2 wt Allele [NCIt concept]
- AKR1C3 wt Allele [NCIt concept]
- COMT wt Allele [NCIt concept]
- CYP11B1 wt Allele [NCIt concept]
- CYP11B2 wt Allele [NCIt concept]
- CYP17A1 wt Allele [NCIt concept]
- CYP19A1 wt Allele [NCIt concept]
- CYP1A1 wt Allele [NCIt concept]
- CYP1B1 wt Allele [NCIt concept]
- CYP21A2 wt Allele [NCIt concept]
- CYP27B1 wt Allele [NCIt concept]
- CYP2R1 wt Allele [NCIt concept]
- CYP3A4 wt Allele [NCIt concept]
- CYP3A5 wt Allele [NCIt concept]
- CYP3A7 wt Allele [NCIt concept]
- CYP7A1 wt Allele [NCIt concept]
- CYP7B1 wt Allele [NCIt concept]
- EBP wt Allele [NCIt concept]
- HSD11B1 wt Allele [NCIt concept]
- HSD11B2 wt Allele [NCIt concept]
- HSD17B1 wt Allele [NCIt concept]
- HSD17B12 wt Allele [NCIt concept]
- HSD17B2 wt Allele [NCIt concept]
- HSD17B6 wt Allele [NCIt concept]
- HSD17B7 wt Allele [NCIt concept]
- HSD3B1 wt Allele [NCIt concept]
- HSD3B2 wt Allele [NCIt concept]
- SRD5A1 wt Allele [NCIt concept]
- SRD5A2 wt Allele [NCIt concept]
- SULT1E1 wt Allele [NCIt concept]
- UGT1A1 wt Allele [NCIt concept]
- UGT1A4 wt Allele [NCIt concept]
- UGT1A7 wt Allele [NCIt concept]
- UGT1A9 wt Allele [NCIt concept]
- UGT2B15 wt Allele [NCIt concept]
- UGT2B17 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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