Aromatase - CISMeF

Preferred Label : Aromatase;

NCIt synonyms : CYPXIX; Microsomal Monooxygenase; Aromatase Cytochrome P450; p450arom; Cytochrome P450 19A1; Flavoprotein-Linked Monooxygenase; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; EC 1.14.14.14; Estrogen Synthetase; CYP19A1; Cytochrome P-450AROM;

NCIt definition : Aromatase (503 aa, 58 kDa) is encoded by the human CYP19A1 gene. This protein is involved in the conversion of androgens to estrogens.;

NCIt note : Aromatase (CYP19A1) forms an electron-transfer complex with NADPH-cytochrome P450 reductase (POR; CPR) during the aromatization reaction. (J Steroid Biochem Mol Biol. 2010; 118: 203-206. doi: 10.1016/j.jsbmb.2009.11.010);

NCI Metathesaurus CUI : CL360009;

Details

Origin ID

C16307;

UMLS CUI

C3254086;

Currated CISMeF NLP mapping
- aromatase [MeSH Descriptor]
- aromatase [MeSH concept]
OMIM relation
- Cytochrome p450, family 19, subfamily a, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP19A1 protein, human [MeSH Supplementary Concept]
- CYP19A1 protein, human [MeSH concept]
- Cytochrome p450 CYP19A1 enzyme (substance) [SNOMED CT concept]
- aromatase [MeSH Descriptor]
- aromatase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CYP19A1 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Resveratrol [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Oxidoreductase [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Endometriosis [NCIt concept]
- Gynecomastia [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Estrogen Metabolic Process [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Maturation [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Anastrozole [NCIt concept]
- Exemestane [NCIt concept]
- Letrozole [NCIt concept]

Keyword's position in hierarchy(ies) :

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