Preferred Label : Letrozole;
NCIt synonyms : 4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile;
NCIt related terms : Femara;
NCIt definition : A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a
third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits
aromatase, which may result in growth inhibition of estrogen-dependent breast cancer
cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum
of the cell and found in many tissues including those of the premenopausal ovary,
liver, and breast, catalyzes the aromatization of androstenedione and testosterone
into estrone and estradiol, the final step in estrogen biosynthesis.;
Alternative definition : NCI-GLOSS: A drug used to treat advanced breast cancer in postmenopausal women. Letrozole
causes a decrease in the amount of estrogen made by the body. It is a type of aromatase
inhibitor.;
UNII : 7LKK855W8I;
InChIKey : HPJKCIUCZWXJDR-UHFFFAOYSA-N;
CAS number : 112809-51-5;
Drug name : Femara; Fempro;
Molecule name : CGS 20267; CGS-20267;
Chemical formula : C17H11N5;
NSC code : 719345;
ChEBI ID : CHEBI:6413;
Codes from synonyms : 31670; NSC0719345; CDR0000507522; CDR0000045421; 304;
Origin ID : C1527;
UMLS CUI : C0246421;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- letrozole [International Nonproprietary Name]
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
