aromatase - CISMeF

Preferred Label : aromatase;

MeSH definition : An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.;

MeSH synonym : cyp 19; protein, cyp19; estrogen synthetase; cyp19; cytochrome p-450 cyp19; cytochrome p-450(arom); cytochrome p450 19; androstenedione aromatase; p450arom; estrogen synthase; cyp19 protein; cytochrome p 450 cyp19; aromatase, androstenedione;

Registry Number MeSH : EC 1.14.14.1;

Wikipedia link : https://en.wikipedia.org/wiki/Aromatase;

Is substance : O;

UNII : EC 1.14.14.1;

Details

Origin ID

D001141;

UMLS CUI

C0003805;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CYP19A1 wt Allele [NCIt concept]
- Cytochrome P450 1A1 [NCIt concept]
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2C18 [NCIt concept]
- Cytochrome P450 2C19 [NCIt concept]
- Cytochrome P450 2C8 [NCIt concept]
- Cytochrome P450 2C9 [NCIt concept]
- Cytochrome P450 2D6 [NCIt concept]
- Cytochrome P450 2E1 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
- Cytochrome p450, family 19, subfamily a, polypeptide 1 [OMIM gene]
- cytochrome P450 family 19 subfamily A member 1 [ORDO Gene]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO term]
Currated CISMeF NLP mapping
- Aromatase [NCIt concept]
False automatic mappings
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO term]
Indexing information
- 3,4-epoxy-5alpha-androstan-17-one [MeSH Supplementary Concept]
- 3-acetoxy-17-picolinylideneandrost-5-ene-16-one [MeSH Supplementary Concept]
- 3-acetoxy-17-picolinylmethylandrost-5-ene-16-one [MeSH Supplementary Concept]
- 3-hydroxy-17-picolinylideneandrost-5-ene-16-one [MeSH Supplementary Concept]
- 6-methoxy-9-methyl-(1,3)dioxolo(4,5-h)quinolin-8(9H)-one [MeSH Supplementary Concept]
- 7-methoxyflavone [MeSH Supplementary Concept]
- HPMA copolymer-Dox-AGM [MeSH Supplementary Concept]
- egonol gentiobioside [MeSH Supplementary Concept]
- egonol gentiotrioside [MeSH Supplementary Concept]
Record concept(s)
- aromatase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP19A1 protein, human [MeSH Supplementary Concept]
- CYP19A1 protein, rat [MeSH Supplementary Concept]
- Cyp19a1 protein, Xenopus [MeSH Supplementary Concept]
- Cyp19a1 protein, mouse [MeSH Supplementary Concept]
- Cyp19a1a protein, zebrafish [MeSH Supplementary Concept]
- Cyp19a1b protein, zebrafish [MeSH Supplementary Concept]
- Familial gynecomastia, due to increased aromatase activity [MeSH Supplementary Concept]
- aromatase deficiency [MeSH Supplementary Concept]
Related MeSH term(s)
- aromatase inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Aromatase [NCIt concept]
- Cytochrome p450 CYP19A1 enzyme (substance) [SNOMED CT concept]
Validated automatic mappings to BTNT
- Cytochrome P450 19A1 [NCIt concept]

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