Preferred Label : Anastrozole;
NCIt synonyms : 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile); Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; Anastrazole;
NCIt related terms : ICI D1033;
NCIt definition : A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical
structure. As a third-generation aromatase inhibitor, anastrozole selectively binds
to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many
tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes
the aromatization of androstenedione and testosterone into estrone and estradiol,
the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole
may inhibit tumor growth. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that is used to decrease estrogen production and suppress
the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase
inhibitor.;
UNII : 2Z07MYW1AZ;
InChIKey : YBBLVLTVTVSKRW-UHFFFAOYSA-N;
CAS number : 120511-73-1;
Drug name : Arimidex;
Molecule name : ICI-D1033; ZD-1033;
Chemical formula : C17H19N5;
NSC code : 719344;
ChEBI ID : CHEBI:2704;
Codes from synonyms : NSC0719344; 20054; CDR0000045504; 33;
Origin ID : C1607;
UMLS CUI : C0290883;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
