NCIt synonyms : Cytochrome P450 Family 3 Subfamily A Member 5 wt Allele; Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 Gene; PCN3; CYPIIIA5; P450PCN3; Cytochrome P450, Subfamily IIIA, Polypeptide 5 Gene; CP35;
NCIt definition : Human CYP3A5 wild-type allele is located in the vicinity of 7q21.1 and is approximately
32 kb in length. This allele, which encodes cytochrome P450 3A5 protein, is involved
in the oxidation of fatty acids, steroids, drugs and xenobiotics. Certain CYP3A5 allelic
variants contribute to the poor metabolizer phenotype.;
NCIt note : The poor metabolizer phenotype is characterized by the inability to use cytochrome
P450-dependent metabolic pathways for drug elimination.;