Drug Metabolism

Preferred Label : Drug Metabolism;

NCIt definition : A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.;

Details

Origin ID

C26633;

UMLS CUI

C0683140;

Automatic exact mappings (from CISMeF team)
- Drug metabolism [OMIConto structure]
- Drug metabolism [OMIConto index]
Currated CISMeF NLP mapping
- drug metabolic process [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- drug metabolic process [GO term]
biological_process_has_initiator_chemical_or_drug
- Pharmacologic Substance [NCIt concept]
biological_process_involves_gene_product
- Catechol O-Methyltransferase [NCIt concept]
- Cytochrome P450 2C18 [NCIt concept]
- Maleylacetoacetate Isomerase [NCIt concept]
- Thiopurine S-Methyltransferase [NCIt concept]
biological_process_is_part_of_process
- Host Defense Mechanism [NCIt concept]
- Resistance Process [NCIt concept]
process_altered_by_allele
- CYP1A2*1 Allele [NCIt concept]
- CYP1A2*11 Allele [NCIt concept]
- CYP1A2*7 Allele [NCIt concept]
- CYP2C19*10 Allele [NCIt concept]
- CYP2C19*12 Allele [NCIt concept]
- CYP2C19*2 Allele [NCIt concept]
- CYP2C19*3 Allele [NCIt concept]
- CYP2C19*4 Allele [NCIt concept]
- CYP2C19*5 Allele [NCIt concept]
- CYP2C19*6 Allele [NCIt concept]
- CYP2C19*7 Allele [NCIt concept]
- CYP2C19*8 Allele [NCIt concept]
- CYP2C19*9 Allele [NCIt concept]
- CYP2C8*2 Allele [NCIt concept]
- CYP2C8*3 Allele [NCIt concept]
- CYP2C8*5 Allele [NCIt concept]
- CYP2C8*7 Allele [NCIt concept]
- CYP2C8*8 Allele [NCIt concept]
- CYP2C9*11 Allele [NCIt concept]
- CYP2C9*12 Allele [NCIt concept]
- CYP2C9*16 Allele [NCIt concept]
- CYP2C9*18 Allele [NCIt concept]
- CYP2C9*2 Allele [NCIt concept]
- CYP2C9*3 Allele [NCIt concept]
- CYP2C9*5 Allele [NCIt concept]
- CYP2C9*6 Allele [NCIt concept]
- CYP2C9*8 Allele [NCIt concept]
- CYP2D6*10 Allele [NCIt concept]
- CYP2D6*11 Allele [NCIt concept]
- CYP2D6*12 Allele [NCIt concept]
- CYP2D6*13 Allele [NCIt concept]
- CYP2D6*14 Allele [NCIt concept]
- CYP2D6*15 Allele [NCIt concept]
- CYP2D6*16 Allele [NCIt concept]
- CYP2D6*17 Allele [NCIt concept]
- CYP2D6*18 Allele [NCIt concept]
- CYP2D6*19 Allele [NCIt concept]
- CYP2D6*20 Allele [NCIt concept]
- CYP2D6*21 Allele [NCIt concept]
- CYP2D6*2N Allele [NCIt concept]
- CYP2D6*3 Allele [NCIt concept]
- CYP2D6*35X2 Allele [NCIt concept]
- CYP2D6*36 Allele [NCIt concept]
- CYP2D6*38 Allele [NCIt concept]
- CYP2D6*4 Allele [NCIt concept]
- CYP2D6*40 Allele [NCIt concept]
- CYP2D6*41 Allele [NCIt concept]
- CYP2D6*42 Allele [NCIt concept]
- CYP2D6*44 Allele [NCIt concept]
- CYP2D6*5 Allele [NCIt concept]
- CYP2D6*6 Allele [NCIt concept]
- CYP2D6*7 Allele [NCIt concept]
- CYP2D6*8 Allele [NCIt concept]
- CYP2D6*9 Allele [NCIt concept]
- CYP2E1*1 Allele [NCIt concept]
- CYP2E1*2 Allele [NCIt concept]
- CYP3A4*17 Allele [NCIt concept]
- CYP3A4*18 Allele [NCIt concept]
- CYP3A5*10 Allele [NCIt concept]
- CYP3A5*3 Allele [NCIt concept]
- CYP3A5*6 Allele [NCIt concept]
- CYP3A5*8 Allele [NCIt concept]
- CYP3A5*9 Allele [NCIt concept]
- CYP3A7*2 Allele [NCIt concept]
process_includes_biological_process
- Drug Efflux [NCIt concept]
- Drug Transport Process [NCIt concept]
process_involves_gene
- BPHL Gene [NCIt concept]
- BPHL wt Allele [NCIt concept]
- COMT Gene [NCIt concept]
- COMT wt Allele [NCIt concept]
- CYP1A2 Gene [NCIt concept]
- CYP1A2 wt Allele [NCIt concept]
- CYP1A2*1 Allele [NCIt concept]
- CYP1A2*11 Allele [NCIt concept]
- CYP1A2*7 Allele [NCIt concept]
- CYP2C18 Gene [NCIt concept]
- CYP2C18 wt Allele [NCIt concept]
- CYP2C19 Gene [NCIt concept]
- CYP2C19 wt Allele [NCIt concept]
- CYP2C19*1 Allele [NCIt concept]
- CYP2C19*10 Allele [NCIt concept]
- CYP2C19*12 Allele [NCIt concept]
- CYP2C19*2 Allele [NCIt concept]
- CYP2C19*3 Allele [NCIt concept]
- CYP2C19*4 Allele [NCIt concept]
- CYP2C19*5 Allele [NCIt concept]
- CYP2C19*6 Allele [NCIt concept]
- CYP2C19*7 Allele [NCIt concept]
- CYP2C19*8 Allele [NCIt concept]
- CYP2C19*9 Allele [NCIt concept]
- CYP2C8 Gene [NCIt concept]
- CYP2C8 wt Allele [NCIt concept]
- CYP2C8*2 Allele [NCIt concept]
- CYP2C8*3 Allele [NCIt concept]
- CYP2C8*4 Allele [NCIt concept]
- CYP2C8*5 Allele [NCIt concept]
- CYP2C8*6 Allele [NCIt concept]
- CYP2C8*7 Allele [NCIt concept]
- CYP2C8*8 Allele [NCIt concept]
- CYP2E1 Gene [NCIt concept]
- CYP2E1 wt Allele [NCIt concept]
- CYP2E1*1 Allele [NCIt concept]
- CYP2E1*2 Allele [NCIt concept]
- CYP3A5 Gene [NCIt concept]
- CYP3A5 wt Allele [NCIt concept]
- CYP3A5*10 Allele [NCIt concept]
- CYP3A5*3 Allele [NCIt concept]
- CYP3A5*6 Allele [NCIt concept]
- CYP3A5*8 Allele [NCIt concept]
- CYP3A5*9 Allele [NCIt concept]
- CYP3A7 Gene [NCIt concept]
- CYP3A7 wt Allele [NCIt concept]
- CYP3A7*2 Allele [NCIt concept]
- GSTZ1 Gene [NCIt concept]
- GSTZ1 wt Allele [NCIt concept]
- TPMT Gene [NCIt concept]
- TPMT wt Allele [NCIt concept]
- TPMT*2 Allele [NCIt concept]
- TPMT*3A Allele [NCIt concept]
- TPMT*3C Allele [NCIt concept]
- TPMT*V2 Allele [NCIt concept]
- TPMT*V3 Allele [NCIt concept]
- TPMT*V4 Allele [NCIt concept]
- TPMT*V5 Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

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