Thiopurine S-Methyltransferase

Preferred Label : Thiopurine S-Methyltransferase;

NCIt synonyms : EC 2.1.1.67; TPMT;

NCIt definition : Thiopurine S-methyltransferase (245 aa, 28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.;

NCIt note : Thiopurine S-methyltransferase catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine.;

Details

Origin ID

C21594;

UMLS CUI

C4742656;

Automatic exact mappings (from CISMeF team)
- thiopurine S-methyltransferase [ORDO Gene]
- thiopurine S-methyltransferase activity [GO term]
- thiopurine methyltransferase [MeSH concept]
- thiopurine methyltransferase [MeSH Supplementary Concept]
OMIM relation
- Thiopurine s-methyltransferase [OMIM gene]
See also inter- (CISMeF)
- Thiopurine methyltransferase [LOINC component]
- Thiopurine s-methyltransferase [OMIM gene]
- thiopurine S-methyltransferase [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TPMT protein, human [MeSH Supplementary Concept]
- Thiopurine methyltransferase [LOINC component]
- Thiopurine methyltransferase (substance) [SNOMED CT concept]
- thiopurine methyltransferase [MeSH concept]
- thiopurine methyltransferase [SNOMED Notion]
- thiopurine methyltransferase [MeSH Supplementary Concept]
enzyme_metabolizes_chemical_or_drug
- Azathioprine [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- TPMT Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Thiopurine Methyltransferase Deficiency [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Metabolism [NCIt concept]
- Methylation [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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