Azathioprine - CISMeF

Preferred Label : Azathioprine;

NCIt synonyms : AZTP; AZA;

NCIt related terms : 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine;

NCIt definition : A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.;

UNII : MRK240IY2L;

InChIKey : LMEKQMALGUDUQG-UHFFFAOYSA-N;

CAS number : 446-86-6;

Chemical formula : C9H7N7O2S;

NSC code : 39084;

ChEBI ID : CHEBI:2948;

Codes from synonyms : 00948; 13715;

Détails

Origin ID

C290;

UMLS CUI

C0004482;

Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Azathioprine [ICD-11 Extension code]
- Azathioprine (substance) [SNOMED CT concept]
- Product containing azathioprine (medicinal product) [SNOMED CT concept]
- azaTHIOprine [LOINC component]
- azathioprine [ATC Code]
- azathioprine [Substance BNPC]
- azathioprine [MeSH concept]
- azathioprine [SNOMED Notion]
- azathioprine [MeSH Descriptor]
Validated automatic mappings to BTNT
- azathioprine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Thiopurine S-Methyltransferase [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Azathioprine Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Azathioprine Sodium [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Consulter ci-dessous une sélection des principales ressources :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients