" /> Azathioprine - CISMeF





Preferred Label : Azathioprine;

NCIt synonyms : AZTP; AZA;

NCIt related terms : 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine;

NCIt definition : A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.;

UNII : MRK240IY2L;

InChIKey : LMEKQMALGUDUQG-UHFFFAOYSA-N;

CAS number : 446-86-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 446-86-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C9H7N7O2S;

NSC code : 39084;

ChEBI ID : CHEBI:2948;

Codes from synonyms : 00948; 13715;

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10/05/2024


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