Preferred Label : azathioprine;
MeSH definition : An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine
in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on
Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen.
(Merck Index, 11th ed);
MeSH synonym : azothioprine;
CISMeF synonym : 55774-33-9 (Azathioprine sodium salt);
MeSH hyponym : azathioprine sodium; imurel; imuran; azathioprine sulfate; Immuran; Sodium, Azathioprine; Azathioprine Sodium Salt;
MeSH CAS label : 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-;
MeSH Related Number : azathioprine sulfate; 446-86-6 (Azathioprine); 55372-48-0 (sulfate); azathioprine sodium; AM94R510MS;
Registry Number MeSH : 446-86-6;
Related CAS MeSH : 55372-48-0 (Azathioprine sulfate); AM94R510MS (Azathioprine sodium);
Wikipedia link : https://en.wikipedia.org/wiki/Azathioprine;
Codes EINECS : 207-175-4;
Is substance : O;
UNII : MRK240IY2L;
InChIKey : LMEKQMALGUDUQG-UHFFFAOYSA-N;
Origin ID : D001379;
UMLS CUI : C0004482;
ATC code(s)
Allowable qualifiers
CISMeF manual mappings
Currated CISMeF NLP mapping
Pharmacological action(s)
Record concept(s)
Related MeSH Supplementary Concept(s)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine
in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on
Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen.
(Merck Index, 11th ed)
https://www.cochrane.org/fr/CD015005/CENTRALED_quels-sont-les-benefices-et-les-risques-de-lazathioprine-un-type-de-medicament-qui-affecte-la
2025
United Kingdom
review of literature
french abstract
organ part
Organisms Category
azathioprine
disease
risks and benefits
organizations
disease, nos
drug, nos
affect, nos
multiple sclerosis
risk assessment
affect
pharmaceutical preparations
immune response, nos
persons
azathioprine
multiple sclerosis, nos
multiple sclerosis
---
https://www.cochrane.org/fr/CD000478/CENTRALED_lazathioprine-et-la-6-mercaptopurine-sont-elles-efficaces-pour-le-traitement-de-la-rectocolite
2025
United Kingdom
review of literature
french abstract
azathioprine
hemorrhage, nos
Mercaptopurine
mercaptopurine
azathioprine
proctocolitis, nos
colitis, ulcerative
---
https://www.rheuma-net.ch/fr/doc/azathioprine-f/viewdocument/347
2024
Switzerland
guideline
Background Treatment
azathioprine
Azathioprine
azathioprine
---
https://www.ema.europa.eu/en/medicines/human/EPAR/jayempi
2021
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
azathioprine
azathioprine
drug approval
europe
azathioprine
immunosuppressive agents
immunosuppressive agents
graft rejection
multiple sclerosis, relapsing-remitting
myasthenia gravis, generalized
arthritis, rheumatoid
Chronic polyarthritis
polyarthritis
chronic disease
crohn disease
colitis, ulcerative
hepatitis, autoimmune
lupus erythematosus, systemic
dermatomyositis
polyarteritis nodosa
pemphigus
pemphigoid, bullous
Behcet syndrome
anemia, hemolytic, autoimmune
purpura, thrombocytopenic, idiopathic
administration, oral
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
myasthenia gravis
arthritis
---
https://www.getaid.org/wp-content/uploads/2020/03/InformationISCovid10mars.pdf
2020
France
coronavirus infections
COVID-19
popular works
azathioprine
rheumatology
disease
adrenal cortical hormone, nos
glucocorticoids
methotrexate
Diseases
Janus Kinase Inhibitors
intestinal diseases
Dermatology
Dermatologists
disease, nos
disease of intestine, nos
methotrexate
dermatology
immunosuppressive agents
azathioprine
biological therapy
corticosteroid therapy
Dermatology
disease
pneumonia, viral
COVID-19
---
https://www.cochrane.org/fr/CD010233/azathioprine-et-6-mercaptopurine-pour-le-maintien-de-la-remission-chirurgicale-dans-la-maladie-de
2019
false
false
false
France
United Kingdom
treatment outcome
review of literature
french abstract
crohn disease
azathioprine
Mercaptopurine
---
http://www.has-sante.fr/portail/jcms/c_2563030/fr/imurel
2015
false
false
false
France
French
evaluation of the transparency committee
imurel
azathioprine
---
https://www.snfge.org/content/cp026-imurelr-azathioprine-et-purinetholr-6-mercaptopurine
2015
false
true
false
France
French
scientific and technical information
azathioprine
Mercaptopurine
azathioprine
mercaptopurine
Mercaptopurine
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38691a-fra.php
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38693a-fra.php
2014
Canada
English
French
pharmacovigilance note
patient education handout
azathioprine
rare diseases
inflammatory bowel diseases
Mercaptopurine
administration, oral
Off-Label use
Hepatosplenic T-cell lymphoma (disorder)
lymphoma, T-Cell
---
http://www.has-sante.fr/portail/jcms/c_1759068/fr/imurel
http://www.has-sante.fr/portail/jcms/c_1759068/fr/imurel-traitements-de-fond-non-biologiques-de-la-polyarthrite-rhumatoide-hors-methotrexate-et-leflunomide
2014
false
France
French
guidelines for drug use
immunosuppressive agents
azathioprine
tablets
administration, oral
insurance, health, reimbursement
treatment outcome
azathioprine
evaluation of the transparency committee
arthritis, rheumatoid
---
http://www.lecrat.eu/?s=Etat+des+connaissances+sur+l%27azathioprine
France
drug information
pregnancy, nos
knowledge
teratogens
pregnancy, high-risk
azathioprine
---
http://www.cochrane.org/fr/CD000545
2013
United Kingdom
France
French
meta-analysis
treatment outcome
remission induction
crohn disease
azathioprine
Mercaptopurine
immunosuppressive agents
french abstract
---
http://www.has-sante.fr/portail/display.jsp?id=c_400866
http://www.has-sante.fr/portail/jcms/c_1525573/imurel
2013
false
France
French
corticosteroid therapy
immunosuppressive agents
azathioprine
antimetabolites
tablets
administration, oral
insurance, health, reimbursement
drug therapy, combination
graft rejection
autoimmune diseases
treatment outcome
azathioprine
evaluation of the transparency committee
lupus erythematosus, systemic
arthritis, rheumatoid
hepatitis, autoimmune
purpura, thrombocytopenic, idiopathic
anemia, hemolytic, autoimmune
dermatomyositis
polymyositis
systemic vasculitis
crohn disease
colitis, ulcerative
pemphigus
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63479140
2012
France
summary of product characteristics
package leaflet
azathioprine
tablets
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60211183
2012
France
summary of product characteristics
package leaflet
tablets
azathioprine
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62824288
2012
France
summary of product characteristics
package leaflet
tablets
azathioprine
---
http://www.cochrane.org/fr/CD000478
2012
false
true
false
United Kingdom
France
Mercaptopurine
treatment outcome
secondary prevention
review of literature
french abstract
colitis, ulcerative
azathioprine
---
http://www.lecrat.eu/?s=Azathioprine+-+exposition+paternelle
2011
France
drug information
teratogens
pregnancy, high-risk
azathioprine
pregnancy, nos
paternal exposure
---
http://www.cochrane.org/fr/CD000067
2010
United Kingdom
France
French
meta-analysis
azathioprine
crohn disease
Mercaptopurine
treatment outcome
remission induction
immunosuppressive agents
french abstract
---
http://www.cochrane.org/fr/CD003270
2010
false
true
false
France
United Kingdom
treatment outcome
review of literature
french abstract
asthma
azathioprine
---
http://www.cochrane.org/fr/CD001461
2009
false
true
false
United Kingdom
France
treatment outcome
review of literature
french abstract
arthritis, rheumatoid
azathioprine
---
http://www.em-consulte.com/article/pii/S0399-8320(08)00649-0
10.1016/j.gcb.2008.10.014
2009
France
teaching material
journal article
pharmacology
mercaptopurine
pharmacologist
azathioprine
pharmacogenetics
complication, nos
Intraspinal abscess
Mercaptopurine
azathioprine
Pharmacogenomic Testing
pharmacogenetics
Mercaptopurine
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64841852
2008
France
French
immunosuppressive agents
azathioprine
antimetabolites
tablets
administration, oral
immunosuppressive agents
azathioprine
antimetabolites
drug approval
graft rejection
autoimmune diseases
adult
child
drug monitoring
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
Mercaptopurine
azathioprine
package leaflet
summary of product characteristics
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63935487
2008
France
French
immunosuppressive agents
infusions, intravenous
azathioprine
azathioprine
drug approval
organ transplantation
immunosuppressive agents
graft rejection
drug therapy, combination
autoimmune diseases
adult
child
continuity of patient care
drug monitoring
drug interactions
pregnancy
breast feeding
antimetabolites
drug evaluation, preclinical
Mercaptopurine
azathioprine
package leaflet
summary of product characteristics
---
http://www.lecrat.eu/?s=Azathioprine
2008
France
French
azathioprine
pregnancy
immunosuppressive agents
breast feeding
azathioprine
drug information
---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Azathioprine.aspx
2008
Canada
popular works
drug information
azathioprine
child
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64204250
2008
France
French
immunosuppressive agents
antimetabolites
tablets
azathioprine
administration, oral
azathioprine
immunosuppressive agents
antimetabolites
graft rejection
drug therapy, combination
autoimmune diseases
organ transplantation
drug approval
adult
child
continuity of patient care
drug monitoring
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
Mercaptopurine
azathioprine
package leaflet
summary of product characteristics
---