" /> CYP3A5*8 Allele - CISMeF





Preferred Label : CYP3A5*8 Allele;

NCIt synonyms : CYP3A5, R28C; Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*8 Allele; CYP3A5, g.3699C T; CYP3A5*8; CYP3A5 8 Allele;

NCIt definition : Human CYP3A5*8 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*8 protein. The CYP3A5*8 allele exhibits a clinically-relevant SNP (g.3699C T) in exon 2 that results in a R28C coding change. This alteration in protein sequence decreases the enzymatic activity of the cytochrome P450 3A5*8 protein.;

NCIt note : Ethnicity Association: African (samples from African Americans and Black Africans were combined);

GenBank Accession Number : NM_000777;

PubMed : 12893984;

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28/04/2024


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