" /> CYP2C8*8 Allele - CISMeF





Preferred Label : CYP2C8*8 Allele;

NCIt synonyms : CYP2C8*8; CYP2C8, R186G; Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*8 Allele; CYP2C8, c.556C G; CYP2C8 8 Allele;

NCIt definition : Human CYP2C8*8 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*8 protein. The CYP2C8*8 allele exhibits a clinically-relevant SNP (c.556C G) in exon 4 that results in a R186G coding change. This alteration in protein sequence severely decreases the enzymatic activity of the cytochrome P450 2C8*8 protein.;

NCIt note : Ethnicity Association: Asian;

GenBank Accession Number : NM_000770;

PubMed : 15716363;

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28/04/2024


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