" /> CYP2D6*18 Allele - CISMeF





Preferred Label : CYP2D6*18 Allele;

NCIt synonyms : Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*18 Allele; CYP2D6, g.4125insGTGCCCACT; CYP2D6*18; CYP2D6(J9); CYP2D6 18 Allele;

NCIt definition : Human CYP2D6*18 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*18 protein. The CYP2D6*18 allele exhibits a nine nucleotide insertion (g.4125insGTGCCCACT) in exon 9. This alteration increased the Km value of the cytochrome P450 2D6*18 protein toward bufuralol, resulting in decreased enzymatic activity.;

NCIt note : Ethnicity Association: Asian;

GenBank Accession Number : NM_000106;

PubMed : 8946471;

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20/05/2024


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