" /> CYP3A4*18 Allele - CISMeF





Preferred Label : CYP3A4*18 Allele;

NCIt synonyms : CYP3A4, L293P; CYP3A4*18; Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*18 Allele; CYP3A4, g.20070T C; CYP3A4 18 Allele;

NCIt definition : Human CYP3A4*18 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type allele, encodes cytochrome P450 3A4*18 protein. The CYP3A4*18 allele exhibits a clinically-relevant SNP (g.20070T C) in exon 10 that results in a L293P coding change. This alteration in protein sequence dramatically increases the enzymatic activity of the cytochrome P450 3A4*18 protein.;

NCIt note : Ethnicity Association: Caucasian;

PubMed : 11714865;

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28/04/2024


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