NCIt synonyms : P3-450; P450(PA); Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 wt Allele; CP12;
NCIt definition : Human CYP1A2 wild-type allele is located within 15q24 and is approximately 8 kb in
length. This allele, which encodes cytochrome P450 1A2 protein, is involved in the
metabolism of drugs and xenobiotics. Certain allelic variants of the CYP1A2 gene contribute
to the poor metabolizer phenotype, which is characterized by the inability to use
cytochrome P450-dependent metabolic pathways for drug elimination. Functional polymorphisms
in the CYP1A2 gene may increase the risk of pancreatic cancer in smokers.;