" /> CYP2D6*35X2 Allele - CISMeF





Preferred Label : CYP2D6*35X2 Allele;

NCIt synonyms : Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*35X2 Allele; CYP2D6*35X2; CYP2D6 35X2 Allele;

NCIt definition : Human CYP2D6*35X2 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, an amplification variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*35 protein. The CYP2D6*35 allele exhibits four SNPs (g.31G A; g.1661G C; g.2850C T; g.4180G C) that result in three coding changes (V11M; R296C; S486T). The CYP2D6*35X2 allele has two copies of the CYP2D6*35 allelic variant. This duplication increases the enzymatic activity of the cytochrome P450 2D6*35 protein in subjects who carry this allele.;

NCIt note : Ethnicity Association: Caucasian;

GenBank Accession Number : NM_000106;

PubMed : 9511177;

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Keyword's position in hierarchy(ies) : arborescence

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20/05/2024


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