GSTZ1 wt Allele

Preferred Label : GSTZ1 wt Allele;

NCIt synonyms : Glutathione S-Transferase Zeta 1 wt Allele; MAI; MAAI; Glutathione Transferase Zeta 1 Gene; GSTZ1-1; MAAID; Glutathione S-Transferase, Zeta-1 Gene;

NCIt definition : Human GSTZ1 wild-type allele is located in the vicinity of 14q24.3 and is approximately 11 kb in length. This allele, which encodes maleylacetoacetate isomerase protein, plays a role in the metabolism of glutathione, aromatic amino acids, dichloroacetic acid and maleylacetoacetate. Various haplotypes of this gene affect the rate of metabolism of dichloroacetate (DCA) and other halogenated carboxylic acids. Mutations in the gene are associated with maleylacetoacetate isomerase deficiency.;

NCI Metathesaurus CUI : CL1906741;

GenBank Accession Number : U86529;

Details

Origin ID

C199332;

OMIM relation
- Glutathione s-transferase, zeta-1 [OMIM gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 14q24.3 [NCIt concept]
gene_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Phenylalanine Metabolism Pathway [NCIt concept]
- Tyrosine Metabolism Pathway [NCIt concept]
gene_plays_role_in_process
- Biogenic Amine Metabolic Process [NCIt concept]
- Drug Metabolism [NCIt concept]

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